Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria
AssigneeWyeth Holdings Corporation
InventorsRasappa G. Arumugham, Maria Fortuna-Nevin, Michael A. Apicella, Bradford W. Gibson
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Abstract
Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of the lipopolysaccharide, the conjugate eliciting a cross reactive immune response against heterologous strains of the gram negative bacteria.
Claims8
An antigenic conjugate comprising a carrier protein covalently bonded to the conserved portion of an isolated lipopolysaccharide of Neisseria meningitidis, wherein said conserved portion of the lipopolysaccharide comprises GlcNAc-Hep2phosphoethanolamine-KDO2-Lipid A, said conjugate eliciting a cross reactive immune response against heterologous strains of Neisseria meningitidis.
An antigenic conjugate comprising the carrier protein diptheria toxin CRM197 covalently bonded to the conserved portion of an isolated lipopolysaccharide of Neisseria meningitidis with long chain N-succinimidyl-3-(2-pyridyldithio)-propionate, and bromacetic acid-N-hydroxysuccinimide ester, wherein said conserved portion of the lipopolysaccharide comprises GlcNAc-Hep2phosphoethanolamine-KDO2-Lipid A, said conjugate eliciting a cross reactive immune response against heterologous strains of Neisseria meningitidis.
Dependencies are inferred from the claim text.