Composition containing anti-MIF antibody
AssigneeThe Picower Institute for Medical Research
InventorsRichard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
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Abstract
The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
Claims9
A pharmaceutical composition comprising an anti-Migration Inhibitory Factor (MIF) antibody in a suitable pharmaceutical carrier, wherein the MIF has a molecular weight of approximately 12.5 kDa as determined by SDS PAGE, and wherein the anti-MIF antibody is a monoclonal antibody that binds to and neutralizes biological activity of the 12.5 kDa MIF and the anti-MIF antibody is present in an amount suitable for administration to a patient in a dosage range that is therapeutically effective for treating a condition or disease caused by cytokine-mediated toxicity.
An article of manufacture comprising packaging material and a pharmaceutical composition contained within the packaging material, said pharmaceutical composition comprising an anti-Migration Inhibitory Factor (MIF) antibody wherein:
- the MIF has a molecular weight of approximately 12.5 kDa as determined by SDS PAGE and the anti-MIF antibody is a monoclonal antibody that binds to and neutralizes biological activity of the 12.5 kDa MIF;
- the anti-MIF antibody is present in an amount that is therapeutically effective for treating a condition or disease caused by cytokine-mediated toxicity;
- and
- said packaging material includes a label that indicates that the anti-MIF antibody is therapeutically effective for treating a condition or disease caused by cytokine-mediated toxicity.
Dependencies are inferred from the claim text.