Method for treating inflammatory conditions using an antibody to MIP-3α
AssigneeSchering Corporation
InventorsElizabeth R. Oldham, Bernhard Homey, Marie Caroline Dieu-Nosjean, Christophe Caux, Albert Zlotnik
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Abstract
Agonists or antagonists of MIP-3α, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the MIP-3α chemokine is specifically capable of inducing migration of a skin cell subset.
Claims22
A method for modulating migration of a lymphoid cell or a myeloid cell within or to the skin of a mammal suffering from inflammation, said method comprising administering to said mammal an effective amount of an antibody to MIP-3α, wherein said MIP-3α is a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2, SEQ ID NO:
- 4, or SEQ ID NO:
- 6, each of said amino acid sequences being without a signal sequence, whereby administration of said antibody ameliorates inflammation.
Dependencies are inferred from the claim text.