Method of treatment with IL-9 conjugate
AssigneeLudwig Institute for Cancer Research
InventorsJacques Van Snick, Jean Christophe Renauld, Mélisande Richard
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Abstract
The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.
Claims11
A method for reducing activity of interleukin-9 in a subject suffering from a pathological condition associated with IL-9 activity, comprising administering to said subject an amount of a conjugate of IL9 and a carrier sufficient to induce production of IL-9 specific antibodies which bind to and reduce activity of IL-9 in said subject, to alleviate said pathological condition associated with IL-9, wherein said pathological condition is selected from the group consisting of asthma, mast cell activation, eosinophilia, and allograft rejection.
Dependencies are inferred from the claim text.