Loading patent…
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsSamuel Davis, JoAnne Bruno, Mitchell Goldfarb, Thomas H. Aldrich, Peter C. Maisonpierre, Czeslaw Radziejewski, Pamela F. Jones, George D. Yancopoulos
Estimating the term…
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
A method of blocking blood vessel growth in a human comprising administering an effective amount of a composition comprising isolated and purified human TIE-2 ligand as set forth in SEQ ID NO:6.
A method of inhibiting TIE-2 ligand 1-mediated blood vessel growth in a mammal comprising administering to the mammal an effective amount of an isolated and purified TIE-2 ligand as set forth in SEQ ID NO:6.
Dependencies are inferred from the claim text.