Dry powder for inhalation
AssigneeJago Research AG
InventorsManfred Keller, Rudi Müller-Walz
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Abstract
The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. One of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.
Claims15
A dry powder formulation for inhalation in the form of an ordered mixture, comprising
- a) a pharmaceutically inactive carrier having particles of noninhalable particle size,
- b) a finely divided pharmaceutically active compound having particles of inhalable particle size, said pharmaceutically active compound being selected from the group consisting of formioterol, ipratropium, tiotropium and pharmaceutically acceptable salts thereof, and
- c) magnesium stearate adhering to said particles of said pharmaceutically inactive carrier, the magnesium stearate being in an amount of 0.1 to 2% by weight, based on the total weight of the formulation, said amount being sufficient to provide the formulation with an improved resistance to moisture.
Dependencies are inferred from the claim text.