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US 6,645,359 B1Granted
Biosensor
AssigneeRoche Diagnostics GmbH
InventorsRaghbir S. Bhullar, Christopher D. Wilsey, Brian S. Hill
Life of this patent
Estimating the term…
Abstract
A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
Claims36
A biosensor comprising:
- a bottom plate element formed to include a first surface, a pre-determined reaction zone on the first surface, and a recess formed in the first surface and positioned adjacent to and circumscribing at least a portion of the reaction zone;
- and
- a reagent coated on at least a portion of the reaction zone;
- and
- a top plate element extending across the reagent and cooperating with the bottom plate element to define a gap, the gap having a sample opening and sized to transport a liquid sample from the opening to the reagent, wherein at least a portion of the recess is positioned in the gap between the sample opening and the reagent.
2 more elements
A biosensor comprising:
- a plate element formed to include a first surface, a pre-determined reaction zone on the first surface, and a recess formed in the first surface and positioned adjacent to and circumscribing at least a portion of the reaction zone;
- a reagent coated on at least a portion of the reaction zone;
- and
- electrodes positioned on the reaction zone and the reagent engages at least a portion of the electrodes,
- wherein the plate element includes discrete recesses and the electrodes cooperate to define an electrode array with a pre-determined pattern and the recesses are positioned within the pattern.
2 more elements
A biosensor comprising:
- a bottom plate element including a first surface formed to include a recess therein;
- a reagent coated on the first surface adjacent to the recess;
- and
- a top plate clement extending across the reagent, being coupled to the bottom plate element, and cooperating with the bottom plate element to define a gap, the gap having a sample opening and sized to transport a liquid sample from the opening to the reagent, wherein at least a portion of the recess is positioned in the gap between the sample opening and the reagent and the recess circumscribes at least a portion of the reagent.
1 more element
A biosensor comprising:
- a bottom plate element including a first surface formed to include at least two spaced-apart recesses therein;
- an array defining an electrode pattern,
- a reagent positioned on the first surface adjacent to the recess;
- and
- a top plate element coupled to the bottom plate element, wherein at least one of the recesses is positioned within the electrode pattern of the array.
2 more elements
An electrode set, comprising:
- a plate element formed to include recesses therein,
- electrodes positioned on the plate element and cooperating to define an interdigitated electrode array, and
- a reagent positioned on at least a portion of the electrodes, wherein at least one recess circumscribes at least a portion of the electrode array and wherein at least one recess is positioned within the electrode array.
A method of forming a biosensor, the method comprises the steps of:
- providing a bottom plate element;
- laser ablating recesses in the bottom plate element;
- applying a reagent onto the plate to define a reaction zone, wherein the at least one recess circumscribes at least a portion of the reaction zone;
- and
- coupling a top plate element to the bottom plate element so that the top plate element extends across the reagent, cooperates with the bottom plate element to create a gap having a liquid sample opening and at least a portion of at least one recess is positioned in the gap between the sample opening and the reaction zone.
2 more elements
A biosensor comprising:
- electrodes formed by tracks that cooperate to form an array and leads that extend from the array,
- a plate element formed to include a first surface supporting the electrodes and discrete recesses formed in the first surface on opposite sides of the array, wherein at least one of the recesses is positioned between the leads;
- a reagent coated on at least a portion of the electrodes, and
- a top plate element cooperating with the plate element to define a gap, the gap having a sample opening and sized to transport a liquid sample from the opening to the reagent, wherein at least a portion of the recess is positioned in the gap between the sample opening and the reagent.
1 more element
A biosensor comprising:
- electrodes formed by tracks that cooperate to form an array and leads that extend from the array,
- a plate element formed to include a first surface supporting the electrodes and discrete recesses formed in the first surface on opposite sides of the array, wherein at least one of the recesses is positioned between the leads, and
- a reagent coated on at least a portion of the electrodes,
- wherein the electrodes cooperate to define an electrode array with a pre-determined pattern and the recesses are positioned within the pattern.
1 more element
Dependencies are inferred from the claim text.