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AssigneeOmeros Corporation
InventorsGregory A. Demopulos, Pamela A. Pierce, Jeffrey M. Herz
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A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a μ-opioid agonist.
A method of inhibiting pain and inflammation during an arthroscopic procedure at an operative site within a joint, comprising:
A method of preemptively inhibiting pain and inflammation during an arthroscopic procedure at an operative site within a joint, comprising:
A method of inhibiting pain and inflammation during an arthroscopic procedure at an operative site within a joint, comprising:
A solution for use in the inhibition of pain and inflammation during an arthroscopic procedure at an operative site within a joint, comprising a plurality of pain and inflammation inhibitory agents in a liquid carrier, the plurality of agents being selected to act on a plurality of differing molecular targets, the concentration of each agent within the solution being the concentration of that agent which is desired to be delivered locally to achieve a level of inhibitory effect at the arthroscopic operative site and that results in a plasma concentration that is less than a plasma concentration that would be required to achieve the same level of inhibitory effect at the arthroscopic operative site when delivered systemically, the agents collectively being effective for inhibiting pain and inflammation at the arthroscopic operative site during the procedure.
A solution for use in the inhibition of pain and inflammation during an arthroscopic procedure at an operative site within a joint, comprising a plurality of pain and inflammation inhibitory agents in a liquid carrier, the plurality of agents being selected to act on a plurality of differing molecular targets, each of the agents included at a concentration that is sufficient to provide a predetermined level of pain/inflammation inhibitory effect at the arthroscopic operative site, when locally applied, in the absence of metabolic transformation occurring prior to delivery to the arthroscopic operative site, and that is less than a concentration which would be required to provide the same predetermined level of inhibitory effect at the arthroscopic operative site if applied in a manner which would entail metabolic transformation of the agents occurring prior to delivery to the arthroscopic operative site, the agents collectively being effective for inhibiting pain and inflammation at the arthroscopic operative site during the procedure.
Dependencies are inferred from the claim text.