Iontophoresis device

A method of transdermally or transmucosally administering a prostaglandin via an iontophoresis device having a first electrode structure containing a prostaglandin, a second electrode structure containing a prostaglandin, and a power supply electrically connected between the first and second electrode structures and equipped with constant-current supplying means and polarity inverting means, the first and the second electrode structures including stabilizing means for inhibiting hydrolysis of the prostaglandin during storage, the stabilizing means being a drug retainer which retains a prostaglandin in a dry condition, and wherein a stabilizing agent for chemically stabilizing a prostaglandin or a dissolution promoter is added to the stabilizing means, the method comprising:

• applying the first and second electrode structures to an administration area of a patient,
• applying a direct current, pulse direct current, or pulse depolarized direct current from the power supply to the patient via the first and second electrodes for a direct current energization period of 1 to 12 hours;
• and
• inverting the polarity thereof for a polarity inverting period of 1 minute to 4 hours.