Back to results
US 6,642,433 B1Granted
Fgl-2 knockout mice
AssigneeTrillium Therapeutics Inc.
InventorsGary Levy, Philip Marsden, Laisum Fung
Life of this patent
Estimating the term…
Abstract
A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomerulonephritis; acute respiratory disease syndrome, Whipple's disease, cancer and for developing therapies to treat these diseases.
Claims12
A nucleic acid construct comprising in the 5′ to 3′ direction a promoter;
- a nucleic acid sequence from an Fgl-2 gene or a portion thereof and a marker sequence, wherein the Fgl-2 gene is disrupted by the marker sequence.
A nucleic acid construct as illustrated in FIG. 1a.
Dependencies are inferred from the claim text.