Photocleavable and acid cleavable linkers for combinatorial chemistry
AssigneePharmacopeia Drug Discovery, Inc.
InventorsVinh D. Tran, Vu Van Ma, Ruiyan Liu
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Abstract
A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R1 is —NO2 or —CHO; R2 is —OCH3, —CHO or —H; R3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3-12. A substrate of solid phase synthesis of the formula III is also disclosed.
Claims19
A composition of the formula II:
- wherein:
- R1 is —NO2 or —CHO;
- R2 is —OCH3, —CHO —H;
- R3 is chosen from the group consisting of hydroxyl, t-butoxy and a solid support having a plurality of amino groups, or R3 together with the carbonyl to which it is attached forms an activated ester;
- and n=1 or 3-12.
A composition of the formula III:
- wherein:
- NH represents a solid support having a plurality of amino groups and R2 is —OCH3, —CHO or —H;
- and n=1 or 3-12.
Dependencies are inferred from the claim text.