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US 6,642,410 B2Granted
Substituted benzylthioacetic acids and esters
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
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Abstract
Styryl benzylsulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: wherein R1 through R10 are defined herein; or a pharmaceutically acceptable salt thereof.
Claims3
A compound of formula III:
- wherein:
- at least three of R1, R2, R3, R4 and R5 are independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl, and the balance of said R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl.
A compound of the formula V:
- wherein:
- Q is
- Y is hydrogen;
- and
- X is selected from the group consisting of 4-hydroxy, 4-amino and 4-sulfamyl.
2 more elements
Dependencies are inferred from the claim text.