US 6,642,398 B2 · Mono-and disubstituted 3-propyl gamma-aminobutyric acids

Abstract

The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

Claims28

Dependent claims

A compound of Formula I

or a pharmaceutically acceptable salt thereof wherein:
R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl;
R2 is straight or branched alkyl of from 4 to 8 carbon atoms,
straight or branched alkenyl of from 2 to 8 carbon atoms,
cycloalkyl of from 3 to 7 carbon atoms,
alkoxy of from 1 to 6 carbon atoms,
alkylcycloalkyl,
alkylalkoxy,
alkyl OH,
alkylphenyl,
alkylphenoxy, and
substituted phenyl.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/324,929Filed 20 Dec 2002 · continuation

Priority

10 Jun 1999

Published

US 2003/0181523 A125 Sep 2003

Granted

4 Nov 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07C 229/32
Having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton: the carbon skeleton being unsaturated and containing…
C07C 229/08
Having only one amino and one carboxyl group bound to the carbon skeleton: the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 229/20
The carbon skeleton being acyclic and saturated: the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
C07C 229/22
The carbon skeleton being acyclic and saturated: the carbon skeleton being further substituted by oxygen atoms

Family

Application60/138,485Us provisional application · filed 10 Jun 1999

PCT/US00/15070Parent of this continuation · filed 31 May 2000

US 2003/0181523 A1Pre-grant publication · published 25 Sep 2003

Application10/009,938Parent of this continuation

US 6,642,398 B2This patent

From the US filing history. Foreign family members aren’t listed.

Mono-and disubstituted 3-propyl gamma-aminobutyric acids

Life of this patent

Mono-and disubstituted 3-propyl gamma-aminobutyric acids

Life of this patent

Abstract

Claims28