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US 6,642,389 B2Granted
Oxazole derivatives
AssigneeHoffmann-La Roche Inc.
InventorsAlfred Binggeli, Markus Boehringer, Uwe Grether, Hans Hilpert, Hans-Peter Maerki, Markus Meyer, Peter Mohr, Fabienne Ricklin
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel oxazole compounds which act as PPARα and PPARγ agonists and are accordingly useful for the treatment of diseases modulated by PPARα and PPARγ such as diabetes.
Claims27
A compound of the formula
- wherein
- R1 is aryl or heteroaryl;
- R2, R3, R4 and R6 are independently selected from the group consisting of hydrogen, hydroxy, lower-alkenyl, halogen, lower-alkyl and lower-alkoxy, wherein at least one of R2, R3, R4 and R6 is not hydrogen, or
- R2 and R6 are independently selected from the group consisting of hydrogen, hydroxy, lower-alkenyl, halogen, lower-alkyl and lower-alkoxy, and R3 and R4 are bonded to each other to form a ring together with the carbon atoms to which they are attached, and R3 and R4 together are —CH═CH—S—, —S—CH═CH—, —CH═CH—O—, —O—CH═CH—, —CH═CH—, —CH═CH—, —(CH2)3-5—, —O—(CH2)2-3— or —(CH2)2-3—O—;
- R5 is lower-alkoxy or lower-alkenyloxy;
- R7 is hydrogen or lower-alkyl;
- n is 1, 2 or 3;
- wherein the bond between the carbon atom Ca and the carbon atom Cb is a carbon carbon single or double bond;
- and pharmaceutically acceptable salts and esters thereof.
6 more elements
(S)-2-methoxy-3-{4-2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
Dependencies are inferred from the claim text.