Process for the synthesis of beta-lactam derivatives
AssigneeAntibioticos S.p.A.
InventorsWalter Cabri, Enrico Siviero, Paola Luigia Daverio, Tania Cristiano, Claudio Felisi, Davide Longoni
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Abstract
The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C1-C4 alkyl ester is used as a solvent for the carbamoylation reaction.
Claims8
A process for the preparation of Cefuroxime acid or a corresponding pharmaceutically acceptable salt or ester which comprises the carbamoylation of (6R,7R)-7-[[2-furanyl(sin-methoxyimino)acetyl]amino]-3-hydroxymethylceph-3-em-4-carboxylic acid with an activated isocyanate, in the presence of a carbonic acid C1-C4 alkyl ester as solvent for said carbamoylation reaction, and the optional formation of the salt or ester from Cefuroxime acid.
Dependencies are inferred from the claim text.