Secreted polypeptides that stimulate release of proteoglycans from cartilage
AssigneeGenentech, Inc.
InventorsEllen Filvaroff, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
Life of this patent
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Abstract
The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims11
An isolated polypeptide having at least 80% amino acid sequence identity to:
- (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2);
- (b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide;
- or
- (c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209526;
- wherein the polypeptide is able to stimulate release of proteoglycans from cartilage.
An isolated polypeptide comprising:
- (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2);
- (b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide;
- or
- (c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited able ATCC accession number 209526.
An isolated polypeptide comprising the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2).
An isolated polypeptide comprising the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide.
An isolated polypeptide comprising the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209526.
Dependencies are inferred from the claim text.