Receptor that binds trail
AssigneeImmunex Corporation
InventorsCharles Rauch, Henning Walczak
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Abstract
A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
Claims41
A purified TRAIL-R polypeptide selected from the group consisting of:
- a) the TRAIL-R polypeptide of SEQ ID NO:2;
- and
- b) a fragment of the polypeptide of (a), wherein said fragment binds TRAIL.
A purified TRAIL-R polypeptide comprising an amino acid sequence that is at least 80% identical to the amino acid sequence presented in SEQ ID NO:2 wherein said polypeptide binds TRAIL.
A purified polypeptide encoded by a DNA comprising the nucleotide sequence of SEQ ID NO:1.
A purified polypeptide comprising amino acids x to 210 of SEQ ID NO:2, wherein x represents an integer from 51 to 59, wherein said polypeptide binds TRAIL.
A polypeptide of claim wherein said polypeptide comprises amino acids 52 to 210 of SEQ ID NO:2.
A purified polypeptide comprising amino acids 94 to 178 of SEQ ID NO:2, wherein said polypeptide binds TRAIL.
A purified soluble TRAIL-R polypeptide comprising an amino acid sequence that is at least 80% identical to the sequence of amino acids 54 to 210 of SEQ ID NO:2, wherein said polypeptide binds TRAIL.
Dependencies are inferred from the claim text.