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US 6,642,357 B1Granted
Process for preparing modified proteins
AssigneeThe Scripps Research Institute
InventorsStephen B. H. Kent, Martina Schnolzer-Rackwitz
Life of this patent
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Abstract
Modified proteins are represented by the formula R-L-R′, wherein R and R′ are peptides or pseudopeptides linked to one another by linkage L. Linkage L may be either a thiol ester pseudopeptide backbone linkage or a selenol ester pseudopeptide backbone linkage.
Claims7
A modified protein represented by the formula:
- R-L-R′
- wherein
- R and R′ are the same or different and are each a residue of a peptide or pseudopeptide;
- and
- L represents a thiol ester pseudopeptide backbone linkage;
- wherein both the peptide and pseudopeptide include from two to one hundred amino acid residues;
- wherein the peptide or pseudopeptide of each R and R′ includes a terminal residue;
- wherein the thiol ester pseudopeptide backbone linkage L links the terminal residue of R with the terminal residue of R′;
- and
- wherein the thiol ester pseudopeptide backbone linkage is represented by —CO—S—CH2—CO—;
- with the following provisos:
- R and R′ each independently have a length of between 2 and 100 amino acid residues;
- and
- at least one of R and R′ has a length of at least 50 amino acid residues.
11 more elements
A modified protein represented by the formula:
- R-L-R′
- wherein
- R and R′ are the same or different and are each a residue of a peptide or pseudopeptide;
- and
- L represents a selenol ester pseudopeptide backbone linkage;
- wherein both the peptide and pseudopeptide include from two to one hundred amino acid residues;
- wherein the peptide or pseudopeptide of each R and R′ includes a terminal residue;
- and
- wherein the selenol ester pseudopeptide backbone linkage L links the terminal residue of R with the terminal residue of R′.
6 more elements
Dependencies are inferred from the claim text.