Implant comprising calcium cement and hydrophobic liquid
AssigneesRobert Mathys Stiftung, Stratec Medical AG
InventorMarc Bohner
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Abstract
A composition including a hydraulic cement for implantation in a human or animal body. The hydraulic cement includes a first component, a second component, and a third component. The first component includes a calcium source while the second component includes water. The third component is a hydrophobic liquid. The composition hardens after mixing of the components, and results in a cement with open macroporosity enabling a rapid bone ingrowth.
Claims62
A composition comprising a hydraulic cement for implantation in a human or animal body, said hydraulic cement comprising a first component comprising a calcium source, and a second component comprising water, wherein:
- A) said composition comprises a third component comprising a hydrophobic liquid that is able to form an emulsion when admixed to said first and second components of said hydraulic cement;
- B) said composition hardens after mixing together of said three components by the action of said water with said first component;
- C) said second component further comprises a surfactant or emulsifier;
- D) said composition has a Ca/P molar ratio comprised between 1.0 and 20.0;
- and
- E) said second component further comprises an additive to control the cement setting time, said additive being either a liquid substance or a solid substance soluble in water and comprising a substance chosen from the group consisting of pyrophosphate, citrate, magnesium orthophosphate or polyphosphateions, amino acids, peptides and proteins.
A composition comprising a hydraulic cement for implantation in a human or animal body, said hydraulic cement comprising a first component comprising a calcium source, and a second component comprising water, wherein:
- A) said composition comprises a third component comprising a hydrophobic liquid that is able to form an emulsion when admixed to said first and second components of said hydraulic cement;
- B) said composition hardens after mixing together of said three components by the action of said water with said first component;
- C) said second component further comprises a surfactant or emulsifier;
- D) said composition has a Ca/P molar ratio comprised between 1.0 and 20.0;
- E) said second component further comprises an additive to control the cement setting time;
- and
- F) said second component further comprises a polymer to control the cement rheology, wherein said polymer is chosen from the group consisting of:
- polyvinyl alcohol and propylene glycol alginate.
A composition comprising a hydraulic cement for implantation in a human or animal body, said hydraulic cement comprising a first component comprising a calcium source, and a second component comprising water, wherein:
- A) said composition comprises a third component comprising a hydrophobic liquid that is able to form an emulsion when admixed to said first and second components of said hydraulic cement;
- B) said composition hardens after mixing together of said three components by the action of said water with said first component;
- C) said second component further comprises a surfactant or emulsifier;
- D) said composition has a Ca/P molar ratio comprised between 1.0 and 20.0;
- E) said second component further comprises an additive to control the cement setting time;
- and
- F) said second component further comprises a polymer to sterically stabilize the first component, wherein said polymer is a polyacrylic acid.
A composition comprising a hydraulic cement for implantation in a human or animal body, said hydraulic cement comprising a first component comprising a calcium source, and a second component comprising water, wherein:
- A) said composition comprises a third component comprising a hydrophobic liquid that is able to form an emulsion when admixed to said first and second components of said hydraulic cement;
- B) said composition hardens after mixing together of said three components by the action of said water with said first component;
- C) said second component further comprises a surfactant or emulsifier;
- D) said composition has a Ca/P molar ratio comprised between 1.0 and 20.0;
- E) said second component further comprises an additive to control the cement setting time;
- and
- F) said composition comprises granules whose diameter is at least 10 times larger than an average diameter of the particles of the first component, wherein the granules have an average diameter in the range of 1 mm to 3 mm.
A composition comprising a hydraulic cement for implantation in a human or animal body, said hydraulic cement comprising a first component comprising a calcium source, and a second component comprising water, wherein:
- A) said composition comprises a third component comprising a hydrophobic liquid that is able to form an emulsion when admixed to said first and second components of said hydraulic cement;
- B) said composition hardens after mixing together of said three components by the action of said water with said first component;
- C) said second component further comprises a surfactant or emulsifier;
- D) said composition has a Ca/P molar ratio comprised between 1.0 and 20.0;
- E) said second component further comprises an additive to control the cement setting time;
- and
- F) wherein the first component comprises beta-tricalcium phosphate and a further substance selected from the group consisting of:
- monocalcium phosphate monohydrate [Ca(H2PO4)2·H2O], monocalcium phosphate [Ca(H2PO4)2], and phosphoric acid [H3PO4].
A method for producing a porous calcium-containing matrix for use in a human or animal body, comprising the steps of:
- emulsifying a freshly mixed calcium-containing hydraulic cement paste and a hydrophobic liquid, wherein the hydrophobic liquid is the discontinuous phase and the freshly mixed calcium-containing hydraulic cement paste is the continuous phase;
- allowing the freshly mixed calcium-containing hydraulic cement paste to harden to thereby entrap the hydrophobic liquid in a hardened cement mixture;
- and
- removing the hydrophobic liquid from the hardened cement mixture to form a porous calcium-containing matrix.
Dependencies are inferred from the claim text.