US 6,642,271 B2Granted

Potentiating compounds

AssigneeArdenia Investments, Ltd.

InventorsOleg Strelchenok, Julian Aleksov

Life of this patent

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Abstract

This invention relates to novel compounds, capable of potentiating the efficacy of therapeutically active compounds, for example cytotoxic compounds used in the treatment of cancer. The novel compounds have been shown to increase the pharmacological activity of a conventional paclitaxel formulation and to make it possible to manufacture a new formulation of paclitaxel, exhibiting improved solubility, improved storage properties, and increased therapeutic efficacy as shown in the enclosed examples.

Claims36

Dependent claims

A compound having a structural formula chosen among the following (I-VI):

Dependencies are inferred from the claim text.

Facts

Application: 10/098,873Filed 15 Mar 2002 · us provisional application
Priority: SE 010170215 May 2001
Published: US 2003/0050343 A113 Mar 2003
Granted: 4 Nov 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 9/1075
Emulsions ; Emulsion preconcentrates; Micelles: microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of…
A61K 31/203
Having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids: retinoic acids ; Salts thereof
A61K 31/40
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having five-membered rings with one nitrogen as the only ring hetero atom,…
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Family

Application60/302,790Us provisional application · filed 3 Jul 2001
US 2003/0050343 A1Pre-grant publication · published 13 Mar 2003
US 6,642,271 B2This patent

From the US filing history. Foreign family members aren’t listed.

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