7-substituted fused ring tetracycline compounds
AssigneeParatek Pharmaceuticals, Inc.
InventorsMark L. Nelson, Laura McIntyre
Life of this patent
Estimating the term…
Abstract
7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
Claims18
A 7-substituted fused ring tetracycline compound of the formula:
- wherein:
- X is CR6R6′;
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- Y and Y′ are each independently optionally substituted C, N, O, or S;
- m is 1 or 2;
- and pharmaceutically acceptable salts thereof.
A 7-substituted fused ring tetracycline compound, wherein said compound is 7-(3′,4′-methylene dioxyphenyl)sancycline and pharmaceutically acceptable salts thereof.
A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal a 7-substituted fused ring tetracycline compound of formula (I):
- wherein:
- X is CR6R6′;
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 and R6′ are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
- Y and Y′ are each independently optionally substituted C, N, O, or S;
- m is 1 or 2;
- and pharmaceutically acceptable salts thereof, such that the tetracycline responsive state is treated.
A method for treating a tetracycline responsive state in a mammal, comprising administering to said mammal 7-(3′,4′-methylene dioxyphenyl)sancycline or a pharmaceutically acceptable salt thereof, such that the tetracycline responsive state is treated.
A pharmaceutical composition comprising a therapeutically effective amount of 7-(3′,4′-methylene dioxyphenyl)sancycline, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.