Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
AssigneeG.D. Searle & Co.
InventorsBradley T. Keller, Kevin C. Glenn, Robert E. Manning
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Abstract
Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co—A reductase inhibitors for the treatment of hyperlipidemic conditions.
Claims18
A composition comprising an ileal bile acid transport inhibitor and an HMG Co-A reductase inhibitor, wherein said ileal bile acid transport inhibitor has a core structure of formula (XYZ):
- wherein:
- n is an integer from 0 to 2.
A pharmaceutical composition, comprising:
- a first amount of an ileal bile acid transport inhibitor,
- a second amount of an HMG Co-A reductase inhibitor, and
- a pharmaceutically acceptable carrier,
- wherein said first and second amounts of said inhibitors together comprise an anti-hyperlipidermic condition effective amount of said inhibitors, and
- wherein the ileal bile acid transport inhibitor has a core structure of formula (XYZ):
- wherein:
- n is an integer from 0 to 2.
A combination therapy method for the treatment of a hyperlipidemic condition in a mammal in need thereof, comprising:
- administering to said mammal a first amount of an ileal bile acid transport inhibitor, and
- administering to said and second amounts of said inhibitors together comprise an anti-hyperlipidermic condition effective amount of said inhibitors, and
- wherein the ileal bile acid transport inhibitor has a core structure of formula (XYZ):
- wherein:
- n is an integer from 0 to 2.
Dependencies are inferred from the claim text.