Thrombopoietin mimetics

A method of treating of thrombocytopenia in a mammal in need thereof which comprises administering to such mammal a therapeutically effective amount of a compound of Formula (II)

• wherein:
• R, R1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, —(CH2)pOR4, —C(O)OR4, nitro, cyano, halogen, aryl, —S(O)nR4, cycloalkyl, protected —OH, —CONR5R6, —NR5R6, phosphonic acid, sulfonic acid, phosphinic acid and —SO2NR5R6, where
• p is 0-6;
• n is 0-2;
• R4 is hydrogen, alkyl, cycloalkyl, C1-C12aryl, substituted alkyl, substituted cycloalkyl and substituted C1-C12aryl and
• R5 and R6 are each independently selected from hydrogen, alkyl, C3-6cycloalkyl, aryl or R5 and R6 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen;
• m is 0-6;
• and
• AR is cyclic or polycyclic aromatic ring containing from 3 to 16 carbon atoms and optionally containing one or more heteroatoms, provided that when the number of carbon atoms is 3 the aromatic ring contains at least two heteroatoms and when the number of carbon atoms is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of:
• alkyl, aryl, substituted cycloalkyl, substituted aryl, aryloxy, hydroxy, alkoxy, cycloalkyl, acyloxy, amino, N-acylamino, nitro, cyano, halogen, —C(O)OR4, —C(O)NR7R8, —S(O)2NR7R8, —S(O)nR4, protected —OH and alkyl substituted with one or more substituents selected from the group consisting of:
• alkoxy, acyloxy, aryl, substituted aryl, amino, N-acylamino, oxo, hydroxy, cycloalkyl, substituted cycloalkyl, —C(O)OR4, —C(O)NR7R8, —S(O)2NR7R8, —S(O)nR4, aryloxy, nitro, cyano, halogen, and protected —OH, where
• R4 is hydrogen, alkyl, cycloalkyl, C1-C12aryl, substituted alkyl, substituted cycloalkyl and substituted C1-C12aryl;
• and
• R7 and R8 are independently hydrogen, cycloalkyl, C1-C12aryl, substituted cycloalkyl, substituted C1-C12aryl, alkyl or alkyl substituted with one or more substituents selected from the group consisting of:
• alkoxy, acyloxy, aryloxy, amino, N-acylamino, oxo, hydroxy, —C(O)OR4, —S(O)nR4, —C(O)NR4R4, —S(O)2NR4R4, nitro, cyano, cycloalkyl, substituted cycloalkyl, halogen, C1-C12aryl, substituted C1-C12aryl and protected —OH, or R7 and R8 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen,
• where R4 is as described above and n is 0-2;
• and
• pharmaceutically acceptable salts, hydrates, solvates and esters thereof.