Modulators of Rho C activity
AssigneeIconix Pharmaceuticals, Inc.
InventorsDongxu Sun, Edward L. Perkins, Stuart Tugendreich, Ving J. Lee
Life of this patent
Estimating the term…
Abstract
Compounds of formula 1 modulate the activity of Rho C: wherein n is 2 to 5, inclusive; R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H, halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl, or lower alkylenedioxy; and pharmaceutically acceptable salts thereof.
Claims16
A compound of formula 1:
- wherein
- n is 1 to 5, inclusive;
- R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H, halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl aryl, or lower alkylenedioxy;
- and
- pharmaceutically acceptable salts thereof.
A method for modulating the activity of a Rho C enzyme, comprising:
- contacting said Rho C enzyme with an effective amount of a compound of formula 1:
- wherein
- n is 1 to 5, inclusive;
- R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H, halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl aryl, or lower alkylenedioxy;
- or pharmaceutically acceptable salts thereof.
A method for treating a disorder mediated by RhoC, comprising:
- administering to a subject having a RhoC-mediated disorder an effective amount of a compound of formula 1:
- wherein
- n is 1 to 5, inclusive;
- R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl, or lower alkylenedioxy;
- or pharmaceutically acceptable salts thereof.
A composition for modulating the activity of a Rho C enzyme, said composition comprising:
- an effective amount of a compound of formula 1
- wherein
- n is 1 to 5, inclusive;
- R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently H halo, lower alkyl, lower alkoxy, lower alkylamino, trifluoromethyl, nitro, lower alkylthio, or two adjacent residues form cycloalkyl, cycloalkenyl, aryl or lower alkylenedioxy;
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.