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US 6,642,253 B2Granted
Thrombin inhibitors comprising an aminoisoquinoline group
AssigneeAkzo Nobel N. V.
InventorsJohannes Bernardus Maria Rewinkel, Cornelis Marius Timmers, Paolo Giovanni Martino Conti
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Abstract
The invention relates to a compound having the formula (I) wherein R1 is cyclopentyl, cyclohexyl or a branched (3-4C)alkyl; R2 is cyclohexyl or phenyl; R3 is H or methyl; and A is an unsubstituted saturated 4, 5 or 6-membered ring; or a pharmaceutically acceptable salt thereof. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-mediated and thrombin-associated diseases.
Claims12
A compound having the formula (I)
- wherein
- R1 is cyclopentyl, cyclohexyl or a branched (3-4C)alkyl;
- R2 is cyclohexyl or phenyl;
- R3 is H or methyl;
- and
- A is an unsubstited saturated 4, 5 or 6-membered ring;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.