Quinuclidine acrylamides

A compound of formula I,

• wherein:
• A represents:
• R represents hydrogen or methyl;
• R1 and R2 are independently hydrogen, or C1-C4 alkyl;
• R3 and R4 are independently hydrogen, C1-C4 alkyl or SAr, provided that at least one of R3 and R4 represents SAr;
• Ar represents a 5- or 6-membered aromatic or heteroaromatic ring containing zero to three nitrogen atoms, zero or one oxygen atom, and zero or one sulfur atom or an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing zero to four nitrogen atoms, zero to one oxygen atom, and zero to one sulfur atom which may optionally be substituted with one or more substituents selected from:
• hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, —CO2R5, —CN, —NO2, —NR6R7, —CF3, 13 OR8;
• R5, R6, R7, and R8 are independently hydrogen, C1-C4 alkyl, aryl, heteroaryl, —(O)R9, —C(O)NHR10, —C(O)R11, —SO2R12;
• or,
• R6 and R7 may together be (CH2)jQ(CH2)k where Q is O, S, NR13 or a bond;
• j is 2 to 7;
• k is 0 to 2;
• R9, R10, R11, R12, and R13, are independently C1-C4 alkyl, aryl, or heteroaryl;
• or an enantiomer thereof, or a pharmaceutically-acceptable salt thereof.