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US 6,642,238 B2Granted
Oxazolidinone thioamides with piperazine amide substituents
AssigneePharmacia & Upjohn Company
InventorJackson B. Hester, Jr.
Life of this patent
Estimating the term…
Abstract
The present invention provides a compound of formula I which have potent activities against gram-positive and gram-negative bacteria.
Claims19
A compound of formula I
- or a pharmaceutically acceptable salt thereof wherein:
- W is NHC(═S)R1,
- R1 is
- (a) H,
- (b) NH2,
- (c) NHC1-4 alkyl,
- (d) C2-4 alkenyl,
- (e) OC1-4 alkyl,
- (f) SC1-4 alkyl,
- (g) (CH2)n-C3-6 cycloalkyl, or
- (h) C1-4 alkyl, optionally substituted with 1-3 F, 1-2 Cl or CN;
- R2 and R3 are independently H, F, Cl or C1-2 alkyl;
- R4 is
- (a) —C(═O)—CH2S(O)n—CH3,
- (b) —C(═S)C1-4 alkyl,
- (c) —C(═O)—(CH2)m—C(═O)—CH3,
- (d) —C(═O)—CH2—O—R10, or
- (e) —CN;
- R10 is —CO2—(CH2)2—OCH3, or —C(═O)—NHC1-4alkyl;
- n is 0, 1 or 2;
- and m is 0 or 1.
18 more elements
N-[((5S)-3-{3-fluoro-4-[4-((2S)-2-acetoxy-2-phenylacetyl)-1-piperazinyl]phenyl}1,3-oxazolidin-5-yl)methyl]propanethioamide.
Dependencies are inferred from the claim text.