3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors

A compound of Formula (IV):

• wherein:
• R is:
• (a) hydrogen;
• (b) —PO(OR5)2 where each R5 is independently hydrogen or alkyl;
• (c) —COR6 where R6 is alkyl;
• or
• (d) —CHR7NR8R9 where R7 is hydrogen or alkyl, and R8 and R9 are independently hydrogen or alkyl;
• or R8 and R9 together with the nitrogen atom to which they are attached form a heterocycloamino ring;
• R1 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl, trifluoromethoxy, F, Cl, Br, or I;
• R2 is hydrogen, alkyl, heteroaryl, alkoxy, hydroxy, F, Cl, Br, or I;
• R3 is hydrogen or alkyl;
• R4 is hydrogen or alkyl;
• ring A is optionally substituted heterocycloamino;
• Het is cycloalkylaminoalkyl, cycloalkylalkylaminoalkyl, heteroaryl, heterocycle, heterocyclylcarbonylalkyl, heterocyclylalkylcarbonyl, or heterocyclylalkyl;
• X is NR8R9 or OR8;
• and
• n is 0 or 1;
• or
• a pharmaceutically acceptable salt thereof.