6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines

A compound of the formula

• wherein R is selected from the group consisting of R2, R2NH—, or R3R4N—R5— wherein
• R2 is selected from the group consisting of C9-C12 alkyl,
• wherein each R6 is independently selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-C4 alkyl, and (CH2)m-phenyl, wherein m is an integer 0-8;
• x is an integer 1-8;
• n is an integer 1-8;
• Z is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthyl, where heterocycle is piperidinyl, pyridinyl, isoxazolyl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperazinyl, benzimidazolyl, thiazolyl, thiophene, furanyl, indolyl, 1,3-benzodioxolyl, tetrahydropyranyl, imidazolyl, tetrahydrothiophene, pyranyl, dioxanyl, pyrrolyl, pyrimidinyl, pyrazinyl, triazinyl, oxazolyl, purinyl, quinolinyl, or isoquinolinyl;
• and M is selected from the group consisting of hydrogen, C1-C4 alkyl,
• wherein each R6′ is independently selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-C4 alkyl, and (CH2)m′-phenyl, wherein m′ is an integer 0-8;
• n′ is an integer 0-8;
• x′ is an integer 1-8;
• Q is hydrogen or C1-C4 alkyl;
• and Z′ is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthyl, where heterocycle is piperidinyl, pyridinyl, isoxazolyl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperazinyl, benzimidazolyl, thiazolyl, thiophene, furanyl, indolyl, 1,3-benzodioxolyl, tetrahydropyranyl, imidazolyl, tetrahydrothiophene, pyranyl, dioxanyl, pyrrolyl, pyrimidinyl, pyrazinyl, triazinyl, oxazolyl, purinyl, quinolinyl, or isoquinolinyl;
• and
• wherein each C9-C12 alkyl or Z is optionally substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of D, E,
• wherein each D is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, and C1-C4 alkoxy;
• each E is independently selected from the group consisting of Hal, OH, C2-C6 alkenyl, and C1-C8 alkyl;
• b is an integer 0-2;
• Z″ is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthyl, where heterocycle is piperidinyl, pyridinyl, isoxazolyl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperazinyl, benzimidazolyl, thiazolyl, thiophene, furanyl, indolyl, 1,3-benzodioxolyl, tetrahydropyranyl, imidazolyl, tetrahydrothiophene, pyranyl, dioxanyl, pyrrolyl, pyrimidinyl, pyrazinyl, triazinyl, oxazolyl, purinyl, quinolinyl, or isoquinolinyl;
• each R6″ is independently selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-C4 alkyl, and (CH2)m″-phenyl, wherein m″ is an integer 0-8;
• n″ is an integer 0-8;
• x″ is an integer 1-8;
• and M′ is selected from the group consisting of hydrogen, C1-C4 alkyl,
• wherein each R6′″ is independently selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-C4 alkyl, and (CH2)m′″-phenyl, wherein m′″ is an integer 0-8;
• n′″ is an integer 0-8;
• x′″ is an integer 1-8;
• Q′ is hydrogen or C1-C4 alkyl;
• and Z′″ is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthyl, where heterocycle is piperidinyl, pyridinyl, isoxazolyl, tetrahydrofuranyl, pyrrolidinyl, morpholinyl, piperazinyl, benzimidazolyl, thiazolyl, thiophene, furanyl, indolyl, 1,3-benzodioxolyl, tetrahydropyranyl, imidazolyl, tetrahydrothiophene, pyranyl, dioxanyl, pyrrolyl, pyrimidinyl, pyrazinyl, triazinyl, oxazolyl, purinyl, quinolinyl, or isoquinolinyl, wherein the groups M′ and Z″ may be optionally substituted with the groups D′, E′ or
• provided M′ is not hydrogen,
• wherein each R6″″ is independently selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-C4 alkyl, and (CH2)m″″-phenyl, wherein m″″ is an integer 0-8;
• x″″ is an integer 0-8;
• Q″ is hydrogen or C1-C4 alkyl or phenyl;
• each D′ is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, and C1-C4 alkoxy;
• each E′ is independently selected from the group consisting of Hal, OH, and C1-C8 alkyl;
• R3 and R4 are selected from the group consisting of hydrogen, C1-C4 alkyl and (CH2)y-phenyl, wherein y is an integer 0-8, with the proviso that R3 and R4 not both be hydrogen;
• R5 is C1-C8 alkylene;
• and
• R1 is isopropyl,
• or a pharmaceutically acceptable salt, an optical isomer, or a hydrate thereof,
• with the proviso that when R2 is the group
• wherein n is 1 or greater;
• R6 is hydrogen, C1-C4 alkyl, or (CH2)m-phenyl;
• and Z is phenyl, heterocycle, or cycloalkyl, that Z is substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of
• wherein D, b, R6″, x″, n″, M′, and Z″ are as previously defined.