Substituted phenyl-piperidine methanone compounds

A compound of formula

• wherein
• R1 a) is unsubstituted phenyl or phenyl substituted by at least one substituent selected from the group R1′consisting of
• halogen,
• trifluoromethyl,
• unsubstituted piperazinyl or piperazinyl substituted by at least one substitutent selected from the group consisting of lower alkyl, -morpholinyl,
• NH-phenyl,
• pyrrolidinyl,
• NH(CH2)n—O-lower alkyl,
• NRaRb,
• NH(CH2)n-cycloalkyl, and
• NH(CH2)n-NRcRd, or is
• b) unsubstituted morpholinyl or morpholinyl substituted by one or two lower alkyl groups, or is
• c) unsubstituted piperazinyl or piperazinyl substituted in the 4-position by the group R1″ which is selected from the group consisting of
• lower alkyl,
• cycloalkyl,
• phenyl,
• benzoxazolyl,
• pyridinyl,
• pyrimidinyl
• pyrazinyl,
• (CH2)n-cycloalkyl,
• (CH2)n-phenyl,
• (CH2)n-hydroxy,
• (CH2)n—CF3,
• (CH2)n—C(O)-morpholinyl,
• (CH2)n—C(O)—N(Re)-unsubstituted phenyl, or —(CH2)n—C(O)—N(Re)-phenyl substituted by lower alkyl or halogen,
• (CH2)n—C(O)—NRfRg,
• C(O)-unsubstituted phenyl or phenyl substituted by a substitutent selected from the group consisitng of
• trifluoromethyl,
• C(O)—(CH2)n-phenyl,
• C(O)—NRhRi,
• C(O)—NRj—(CHRk)n-phenyl,
• C(O)-lower alkyl,
• C(O)—CF3,
• C(O)-cycloalkyl,
• C(O)-morpholinyl,
• C(O)O-lower alkyl,
• C(O)—O—(CH2)n-NRlRm and
• S(O)2-lower alkyl,
• or is
• d) unsubstituted pyrrolidinyl or pyrrolidinyl substituted by at least one group R1′″, which is selected from the group consisting of
• halogen,
• hydroxy,
• ═O,
• NRnRo,
• N(cycloalkyl)2,
• N[(CH2)ncycloalkyl]2,
• NRp—C(O)-cycloalkyl and
• O—(CH2)n-cycloalkyl, or is
• e) unsubstituted piperidinyl or piperidinyl substituted by at least one group R1″″ in the 3 or 4-positionselected from the group consisting of
• hydroxy,
• ═O,
• halogen,
• morpholinyl,
• NRqRr,
• NRs-cycloalkyl,
• NRt—C(O)-cycloalkyl,
• NRu—C(O)-phenyl,
• NRv—C(O)—(CH2)n-phenyl and
• O—(CH2)n-cycloalkyl,
• or is
• f) thiomorpholinyl, 1-oxo-thiomorpholinyl or 1,1-dioxothiomorpholinyl;
• R2 is, independently, selected from the group consisting of hydrogen, halogen, lower alkyl, —NH—(CH2)n—O-lower alkyl pyrrolidinyl and morpholinyl;
• R3/R4 are, independently from each other, trifluoromethyl or halogen;
• R, Ra-v are independently hydrogen or lower alkyl;
• n is 1, 2, 3 or 4;
• and
• m is 0, 1 or 2;
• or a pharmaceutically acceptable acid addition salt thereof.