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US 6,642,221 B1Granted
Vanadium compounds as anti-proliferative agents
AssigneeParker Hughes Institute
InventorsFaith M Uckun, Christopher S Navara
Life of this patent
Estimating the term…
Abstract
Vanadium compounds as anti-proliferative agents. These compounds act to disrupt mitotic and meiotic spindle formation and thus are useful to prevent cell mitosis (proliferation) and meiosis.
Claims7
A method for inhibiting mitosis or meiosis in a non-cancer cell comprising administering to the non-cancer cell an effective mitosis or meiosis inhibiting amount of a vanadium compound having the following structure:
- wherein,
- R1 and R2 are each independently a monodentate ligand or together form a bidentate ligand;
- R3 and R4 are each independently a monodentate ligand or together form a bidentate ligand;
- and
- R5 is a monodentate ligand, or is absent;
- wherein at least one of R1 and R2 or R3 and R4 combine together to form a bidendate ligand selected from the group consisting of acac, Bpy, Hfacac, Cat, Dtc, PH, acetohydroxamic acid, Phen, or a derivative thereof.
3 more elements
A method for treating a non-cancer proliferative disorder in a subject, comprising administering to the subject an effective mitosis inhibiting amount of a vanadium compound of structure II:
- wherein,
- R1 and R2 are each independently a monodendate ligand or together form a bidendate ligand;
- R3 and R4 are each independently a monodendate ligand or together form a bidendate ligand;
- and
- R5 is a monodendate ligand, or is absent;
- wherein (i) at least one of R1 and R2 or R3 and R4 combine together to form a bidendate ligand selected from the group consisting of acac, Bpy, Hfacac, Cat, Dtc, PH, acetohydroxamic acid, Phen, or a derivative thereof, and (ii) at least one of R1, R2, R3, R4 or R5 is a cyclopentadienyl ring.
3 more elements
Dependencies are inferred from the claim text.