Three-dimensional prostheses containing hyaluronic acid derivatives
AssigneeFidia Advanced Biopolymers S.r.l.
InventorsAndrea Pastorello, Marco Radice, Lanfranco Callegaro
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Abstract
A three-dimensional prosthesis is described in the shape of a body part comprising at least one three-dimensional matrix having an essentially fibrous or porous structure and containing a hyaluronic acid derivative, said prosthesis, contains at least two of said three-dimensional matrixes, the first of said three-dimensional matrixes incorporating or being adhered to the second and possible further matrixes, said three-dimensional matrix(es) optionally inicorporating and/or being adhered to a bidimensional perforated matrix and containing a hyaluronic acid derivative. This prosthesis is used for reconstruction of human or animal body part.
Claims29
A three-dimensional prosthesis in the shape of a body part comprising at least one three-dimensional matrix having an essentially fibrous or porous structure and containing at least one hyaluronic acid derivative, said prosthesis, when containing at least two of said three-dimensional matrices, the first of said matrices, incorporating and/or being adhered to the second and possible further matrices, said three-dimensional matrix(ces) optionally incorporating and/or being adhered to a bi-dimensional perforated matrix containing a hyaluronic acid derivative.
A process for preparing a three-dimensional prosthesis comprising a three-dimensional matrix A1 having an essentially fibrous structure incorporating a three-dimensional matrix B having an essentially porous structure, said matrices A1 and B comprising at least one hyaluronic acid derivative,
- said process comprising the following steps:
- a) lining a mold with a layer of non woven tissue comprising a hyaluronic acid derivative;
- b) impregnating said non woven tissue in the mold with an aqueous solution of a quaternary ammonium salt of hyaluronic acid or of a hyaluronic acid derivative selected from the group consisting of N-sulphated hyaluronic acid, O-sulphated hyaluronic acid, the hemiesters of succinic acid with hyaluronic acid and optionally partially salified with heavy metals;
- c) freeze-drying the content of the mold thereby obtaining prostheses having the matrix A1 incorporating the matrix B consisting of a quaternary ammonium salt of hyaluronic acid or a hyaluronic acid derivative as defined above in item b);
- d) optionally converting the quaternary ammonium salt contained in the prostheses coming from step (c) into a hyaluronic acid derivative chosen from the group consisting of esters of hyaluronic acid wherein part or all of the carboxy functions are esterified with alcohols of the aliphatic, aromatic, arylaliphatic, cycloaliphatic or heterocyclic series, and cross-linked esters of hyaluronic acid wherein part or all of the carboxy groups are esterified with the alcoholic functions of the same or a different polysaccharide chain or other chains;
- e) freeze-drying the product coming from (d).
A process for preparing a three-dimensional prosthesis comprising a three-dimensional matrix A2 having an essentially porous structure being adhered to a three-dimensional matrix C having an essentially fibrous structure, said matrices A2 and C, comprising at least one hyaluronic acid derivative, said process comprising the following steps:
- a′) applying a thin layer of an aqueous solution of a quaternary ammonium salt of hyaluronic acid or of a hyaluronic acid derivative selected from the group consisting of N-sulphated hyaluronic acid, O-sulphated hyaluronic acid, the hemiesters of succinic acid with hyaluronic acid and optionally partially salified with heavy metals, to the same or different freeze-dried quaternary ammonium salt of hyaluronic acid or of hyaluronic acid derivative as defined above;
- b′) adhering to the mixture coming from step (a′) a layer of non woven tissue comprising a hyaluronic acid derivative;
- c′) freeze-drying the mixture coming from step (b′) thereby obtaining prostheses wherein the matrix A2 consists of a quaternary ammonium salt as defined above in item a′), adhering to matrix C;
- d′) optionally converting the ammonium salt contained in the prostheses coming from step (c′) into a hyaluronic acid derivative chosen from the group consisting of esters of hyaluronic acid wherein part or all of the carboxy functions are esterified with alcohols of the aliphatic, aromatic, arylaliphatic, cycloaliphatic or heterocyclic series, and cross-linked esters of hyaluronic acid wherein part or all of the carboxy groups are esterified with the alcoholic functions of the same or a different polysaccharide chain or other chains;
- e′) freeze drying the product coming from (d′).
A process for preparing a three-dimensional prosthesis comprising a three-dimensional matrix A2 having an essentially porous structure adhered to a three-dimensional matrix C having an essentially fibrous structure, said matrices A2 and C comprising at least one hyaluronic acid derivative, said process comprising the following steps:
- a″) applying a thin layer of a solution of a hyaluronic acid derivative in a suitable aqueous or organic solvent, said hyaluronic acid derivative being chosen from the group consisting of esters of hyaluronic acid wherein part or all of the carboxy functions are esterified with alcohols of the aliphatic, aromatic, arylaliphatic, cycloaliphatic or heterocyclic series, and cross-linked esters of hyaluronic acid wherein part or all of the carboxy groups are esterified with the alcoholic functions of the same or a different polysaccharide chain or other chains;
- b″) applying to the freeze dried product coming from step (a″) a non woven tissue comprising a hyaluronic acid d derivative;
- c″) freeze-drying the product coming from step (b″).
Dependencies are inferred from the claim text.