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US 6,642,210 B1Granted
2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
AssigneeCV Therapeutics, Inc.
InventorsJeff A. Zablocki, Elfatih O. Elzein, Venkata P. Palle
Life of this patent
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Abstract
N-pyrazole substituted 2-adenosine compounds and methods for using the compounds as A2A-adenosine receptor agonists useful to stimulate mammalian coronary vasodilation for therapeutic purposes and as adjuncts in cardiological imaging.
Claims18
A compound having the formula:
- wherein R1=CH2OH;
- R3 is selected from the group consisting of CO2R20, —CONR7R8, and aryl, wherein the aryl substituent is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, alkyl, and OR20;
- R7 is selected from the group consisting of hydrogen, straight or branched C1-15 alkyl and C3-8 cycloalkyl, wherein the alkyl substituent is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of aryl and CO2R20, and wherein the optional aryl substituent is optionally substituted with halo;
- R8 is selected from the group consisting of hydrogen, straight or branched C115 alkyl and C3-8 cycloalkyl;
- R20 is selected from the group consisting of hydrogen and C1-15 alkyl;
- and wherein R2 and R4 are hydrogen.
3 more elements
Dependencies are inferred from the claim text.