Polynucleotides encoding a novel metalloprotease, MP-1
AssigneeBristol-Meyers Squibb Company
InventorsJian Chen, John N. Feder, Thomas C. Nelson, Stanley R. Krystek, Franck Duclos
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Abstract
The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Claims24
An isolated nucleic acid molecule comprising a polynucleotide sequence selected from the group consisting of:
- (a) an isolated polynucleotide encoding a polypeptide corresponding to amino acids 1 to 414 of SEQ ID NO:
- 2 including the start codon;
- (b) an isolated polynucleotide encoding a polypeptide corresponding to amino acids 2 to 414 of SEQ ID NO:
- 2 minus the start codon;
- (c) an isolated polynucleotide encoding a polypeptide corresponding to amino acids 148 to 414 of SEQ ID NO:
- 2 including the start codon;
- (d) an isolated polynucleotide encoding a polypeptide corresponding to amino acids 149 to 414 of SEQ ID NO:
- 2 minus the start codon;
- (e) an isolated polynucleotide encoding a polypeptide corresponding to amino acids 176 to 414 of SEQ ID NO:
- 2;
- (f) an isolated polynucleotide encoding the MP-1 polypeptide as encoded by the cDNA clone contained in ATCC Deposit No:
- PTA-2766;
- (g) an isolated polynucleotide encoding at least 274 contiguous amino acids of SEQ ID NO:
- 2 having metalloproteinase activity;
- and
- (h) an isolated polynucleotide which represents the complimentary sequence (antisense) of (a), (b), (c), (d), (e), (f) or (g) wherein (a), (b), (c), (d), (e), (f) or (g) have metalloproteinase activity.
Dependencies are inferred from the claim text.