Chlamydia protein, gene sequence and uses thereof
AssigneeAntex Biologics Inc.
InventorsW. James Jackson, John L. Pace
Life of this patent
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Abstract
A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
Claims19
An isolated nucleic acid molecule encoding a Chlamydia high molecular weight (HMW) protein, said HMW protein comprising an amino acid sequence of SEQ ID NO.:
- 2.
An isolated nucleic acid molecule comprising,
- a nucleic acid sequence which hybridizes under conditions comprising 50% formamide and 37° C. to a DNA sequence which is complementary to SEQ ID No.:
- 1 and encodes a protein which is recognized by an antibody that specifically binds to a protein comprising an amino acid sequence of SEQ ID NO.:
- 2.
An isolated nucleic acid molecule comprising nucleotide residues 466 to 3421 of SEQ ID NO.:
- 1, wherein said nucleic acid is obtainable from plasmid pAH342 contained in E.coli BL21 (pAH342) assigned ATCC accession number 985538.
A recombinant vector comprising plasmid pAH342 obtainable from E.coli BL21 (pAH342) having ATCC accession number 985538.
An isolated nucleic acid molecule comprising at least 50 nucleotides of SEQ ID NO.:
- 1 and encoding a fragment of a Chlamydia high molecular weight (HMW) protein, wherein said fragment is recognized by an antibody that specifically binds to a protein comprising an amino acid sequence of SEQ ID NO.:
- 2.
An isolated nucleic acid molecule comprising residues 466 to 1980 of SEQ ID NO.:
- 1, wherein said nucleic acid is obtainable from plasmid pJJ36-J contained in E. coli TOP10 having ATCC accession number PTA-3719.
A recombinant vector comprising plasmid pJJ 36-J obtainable from E.coli TOP10 pJJ 36-J having ATCC accession number PTA-3719.
Dependencies are inferred from the claim text.