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US 6,642,013 B1Granted
Extracellular serine protease
AssigneeThe University of Arkansas for Medical Sciences
InventorsTimothy J. O'Brien, Lowell J. Underwood
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Abstract
The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
Claims3
An ex vivo method of producing activated immune T cells or dendritic cells directed toward TADG-14 having an amino acid sequence of SEQID No. 7, comprising the steps of:
- exposing said immune cells to a TADG-14 protein fragment consisting of an amino acid sequence selected from the group consisting of SEQ ID Nos. 17, 18, 41, 42, 47, 48, 53, 56 and 64, wherein exposure to said TADG-14 protein fragment activates said immune cells, thereby producing activated immune T cells or dendritic cells directed toward TADG-14.
Dependencies are inferred from the claim text.