US 6,642,006 B2 · Transforming growth factor alpha hii

Abstract

The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating would healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

Claims21

Dependent claims

An isolated antibody capable of binding to a polypeptide consisting of an amino acid sequence selected from the group consisting of:

(a) amino acids 215 to 264 of SEQ ID NO:2;
(b) amino acids 1 to 264 of SEQ ID NO:2;
and
(c) amino acids 1 to 374 of SEQ ID NO:2.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

09/227,853Filed 11 Jan 1999 · division

Published

US 2002/0143156 A13 Oct 2002

Granted

4 Nov 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 38/1841
Growth factors; Growth regulators: transforming growth factor [TGF]
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C07K 14/495
Growth factors; Growth regulators: transforming growth factor [TGF]
A61K 48/00
Medicinal preparations containing genetic material which is inserted into cells of the

Transforming growth factor alpha hii

Life of this patent

Transforming growth factor alpha hii

Life of this patent

Abstract

Claims21