Modified carrier particles for use in dry powder inhalers
AssigneeChiesi Farmaceutici S.p.A.
InventorsRossella Musa, Roberto Bilzi, Paolo Ventura, Paolo Chiesi
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Abstract
The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
Claims21
A process for modifying the surface properties of particles for use as carrier particles for the pulmonary administration of micronised drugs by means of dry powder inhalers, comprising the step of subjecting said carrier particles alone to a treatment of a mixer equipped with a rotating element, said mixer operating at a rate of 100 to 300 r.p.m. in order to produce in situ a fine fraction of said carrier particles having a mean aerodynamic diameter of less than 10 μm and a Carr's index of less than 25.
Dependencies are inferred from the claim text.