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US 6,641,841 B2Granted
Tablet composition
AssigneeAjinomoto Co., Inc.
InventorsAkira Yabuki, Masato Kaida, Takahiko Ando, Nobutaka Ninomiya, Masanao Ozaki
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Abstract
A tablet composition containing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and low substituted hydroxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.
Claims6
A process for preparing a tablet comprising:
- mixing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and a disintegrant selected from the group consisting of low substituted hydroxypropylcellulose, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose and croscaramellose sodium, to obtain a mixture,
- granulating said mixture with water which optionally contains a lower alcohol to obtain granules,
- drying said granules,
- and tableting said dried granules to obtain a tablet.
1 more element
Dependencies are inferred from the claim text.