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US 6,641,831 B1Granted
Medical products with sustained pharmacological activity and process for producing them
OwnerJörg Schierholzinventor
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OwnerJörg Schierholzinventor
Estimating the term…
A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B, substance A being more lipophilic than substance B, wherein substance A has a solubility (w/w) in water of from 300 μg/ml to 1 μg/ml, substance B has a higher solubility than that of substance A, at least one of substance A and B is a pharmaceutically active substance, and wherein the amount of substance A or B is respectively from at least an effective amount to 10% by weight, based on the weight of the support material; with the exception of the combinations chlorohexidine/silver sulfadiazine, tri-closane/chlorohexidine, polyethylene gltcol/polyurethane, porous polyethylene with combinations of clotrimazole and triclosane.
A non-degradable medical implant comprising a support material and monolithic distribution of at least two substances or groups of substances molecularly dispersed throughout a polymeric matrix, the at least two substances having different degrees of hydrophilicity for retarded release, of which the first is referred to as substance A and the second is referred to as substance B, substance A being more lipophilic than substance B, wherein substance A has a solubility w/w in water of from 300 μg/ml to 1 μg/ml, substance B has a higher solubility than that of substance A, at least one of substances A and B is a pharmaceutically active substance, and wherein the amount of substance A or B is respectively from at least an effective amount to 10% by weight, based on the weight of the support material.
A non-degradable medical product for implantation comprising a support material and monolithic distribution of at least two substances or groups of substances molecularly dispersed throughout a polymeric matrix, the at least two substances having different degrees of hydrophilicity for retarded release, of which the first is referred to as substance A and the second is referred to as substance B, substance A being more lipophilic than substance B, wherein substance A has a solubility w/w in water of from 300 μg/ml to 1 μg/ml, substance B has a higher solubility than that of substance A, at least one of substances A and B is a pharmaceutically active substance, and wherein the amount of substance A or B is respectively from at least an effective amount to 10% by weight, based on the weight of the support material.
Dependencies are inferred from the claim text.