Herpes virus vectors for dendritic cells
AssigneeBiovex Limited
InventorsRobert Stuart Coffin, Benjamin Chain
Life of this patent
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Abstract
An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dentrictic cells infected with the virus are useful in immunotherapeutic methods of treating disease.
Claims39
An attenuated herpes simplex virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell, which virus lacks a functional UL43 gene and a functional vhs gene.
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes simplex virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell, which virus lacks a functional vhs gene and a functional UL43 gene.
Dependencies are inferred from the claim text.