Sequestrin
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsPatrick E. Duffy, Christian F. Ockenhouse
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Abstract
In this application is described the expression cloning and functional characterization of the CD36-binding domain of Sequestrin. Sequestrin is a surface protein of 215-250 kD size which does not vary in size between parasite strains. The Sequestrin gene appears to be single-copy-number within the genome; noncytoadherent laboratory parasite strains carry the sequestrin gene but fail to express the protein. Sequestrin binds with high affinity to CD36. Sequestrin protein and sequence can be used as a diagnostic, prognostic, and therapeutic tool.
Claims14
An isolated peptide consisting of the amino acid sequence specified in SEQ ID NO:2, or a portion thereof which comprises at least 8 contiguous amino acids, wherein the peptide or portion thereof binds specifically to CD36.
An isolated peptide consisting of the amino acid sequence specified in SEQ ID NO:2, or a portion thereof which comprises at least 10 contiguous amino acids.
An isolated peptide consisting of the amino acid sequence specified in SEQ ID NO:4, or a portion thereof which comprises at least 8 contiguous amino acids, wherein the peptide or portion thereof binds specifically to CD36.
An isolated peptide consisting of the amino acid sequence specified in SEQ ID NO:4, or a portion thereof which comprises at least 10 contiguous amino acids.
Dependencies are inferred from the claim text.