Loading patent…
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, William Brady
Estimating the term…
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin Cγ1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
A method for inhibiting T cell proliferation resulting from binding of B7 and CD28 comprising contacting CD28 positive T cells with a soluble B7 fusion protein so as to bind CD28 on the CD28 positive T cells with the soluble B7 fusion protein and thereby inhibiting T cell proliferation.
A method for inhibiting the binding of CD28 positive T cells to B7 positive B cells comprising contacting the CD28 positive T cells with a soluble B7 fusion protein which recognizes and binds CD28 on the CD28 positive T cells thereby preventing binding of CD28 to the B7 positive B cells.
A method of inhibiting CD28 positive T cell responses comprising reacting B7 positive B cells with a soluble CD28 fusion protein so as to bind the B7 positive B cells with the soluble CD28 fusion protein thereby inhibiting T cell responses caused by the binding of B7 and CD28.
Dependencies are inferred from the claim text.