Milling process for the production of finely milled medicinal substances
AssigneeAventis Pharma S.A.
InventorsNarasimha M. Vemuri, Andrew B. Brown, Jean-Rene Authelin, Patrik Hosek
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Abstract
The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.
Claims12
A method for producing a fine, highly crystalline material product, the method comprising fluid energy milling a crystalline material at a relative humidity of between 30% and 90%.
Dependencies are inferred from the claim text.