Device for photodynamic diagnosis or treatment
AssigneeKarl Storz GmbH & Co. KG
InventorsKlaus M. Irion, Herbert Stepp, Andre Erhardt, Hans Tafelmaier
Life of this patent
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Abstract
An endoscopic or microscopic apparatus for diagnosis by means of a light-induced reaction in biologic tissue “in vivo” which is created by a photo-amboceptor or by autofluorescence is provided. The inventive apparatus is characterized by the feature that at least one reference wavelength λr is provided which is longer by up to 2Δλ at maximum or smaller than the wavelength λs at the point of intersection.
Claims28
A system for diagnosis or therapeutic treatment by means of a light-induced reaction created in biologic tissue “in vivo”, comprising
- a path of an illuminating beam constituted by
- at least one light source with a lamp system generating incoherent light in a wavelength range of at least 400 to 650 nm, and a light-feeding unit which directs the light of the at least one light source onto a tissue region to be diagnosed or therapeutically treated,
- presenting a spectral transmission function T1(λ) matched with the fluorescence excitation spectrum of the light-induced reaction and
- a path of an observation beam constituted by an imaging unit which images the light coming from said tissue region into an image plane, presenting a spectral transmission function Tb(λ) matched with the fluorescence spectrum of the light-induced reaction wherein said spectral transmission function T1(λ) of said path of the illuminating beam and said spectral transmission function Tb(λ) of said path of the observation beam intersect at wavelength λs at which the transmission value of each optical path is not higher than 30%, wherein at least one reference wavelength λr is provided which is longer by up to 2Δλ at maximum or smaller than the wavelength λs at the point of intersection, for which hence applies:
- λs−2Δλ≦λr≦λs+2Δλ
- and starting out from which
- the spectral transmission function T1(λ) of the path of the illuminating beam satisfies the following conditions for at least five wavelengths λr, λr+Δλ, λr+3Δλ, λr−Δλ, and λr−2Δλ:
- |T1(λr − Δλ) − T1(λr − 2Δλ)| > 10% |T1(λr + Δλ) + T1(λr + 3Δλ)| < 5% T1(λr) > 0.5% T1(λr − Δλ) > 0.5% T1(λr − 2Δλ) > 0.5% T1(λr + Δλ) > 0.5% T1(λr + 3Δλ) > 0.3%
- wherein
- 4 nm<Δλ<6 nm.
A system for diagnosis or therapeutic treatment by means of a light-induced reaction in biologic tissue “in vivo”, comprising
- a path of an illuminating beam constituted by
- at least one light source with a lamp system generating incoherent light in a wavelength range of at least 400 to 650 nm, and a light-feeding unit which directs the light of the at least one light source onto a tissue region to be diagnosed or therapeutically treated,
- presenting a spectral transmission function T1(λ) matched with the fluorescence excitation spectrum of the light-induced reaction, and
- a path of an observation beam constituted by an imaging unit which images the light coming from said tissue region into an image plane, presenting a spectral transmission function Tb(λ) matched with the fluorescence spectrum of the light-induced reaction wherein said spectral transmission function T1(λ) of said path of the illuminating beam and said spectral transmission function Tb(λ) of said path of the observation beam intersect at wavelength λs at which the transmission value of each optical path is not higher than 30%, wherein at least one reference wavelength λr is provided which is longer by up to 2Δλ at maximum or smaller than the wavelength λs at the point of intersection, for which hence applies:
- λs−2Δλ≦λr≦λs+2Δλ
- and starting out from which
- the spectral transmission function Tb(λ) of the path of the observation beam satisfies the following conditions for at least five wavelengths λr, λr−Δλ, λr−3Δλ, λr+Δλ, and λr+2Δλ:
- |Tb(λr + Δλ) − Tb(λr + 2Δλ)| > 10% |Tb(λr − Δλ) − Tb(λr − 3Δλ)| < 5% Tb(λr) > 0.5% Tb(λr + Δλ) > 0.5% Tb(λr + 2Δλ) > 0.5% Tb(λr − Δλ) > 0.3% Tb(λr − 3Δλ) > 0.3%
- wherein
- 4 nm<Δλ<6 nm.
Dependencies are inferred from the claim text.