In-line matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) systems and methods of use
AssigneeAgilent Technologies, Inc.
InventorGangqiang Li
Life of this patent
Estimating the term…
Abstract
Mass spectrometry systems and methods are disclosed. Briefly described, one embodiment of the mass spectrometry system, among others, includes a mass spectrometer, a laser generator, and a sample substrate. The mass spectrometer includes a first end and a second end and the laser generator produces a laser radiation beam that travels along a first path. The sample substrate holds a sample at the first end of the mass spectrometer, where the sample produces a plurality of ions that travel along a second path that is substantially parallel the first path but towards the second end of the mass spectrometer.
Claims29
A mass spectrometry system, comprising:
- a mass spectrometer having a first end and a second end, wherein the first end includes a sampling orifice and the second end includes an optic window, and wherein the sampling orifice is in-line with the optic window;
- and
- a laser system located at the second end of the mass spectrometer, so that when the laser system emits laser radiation, the laser radiation travels first through the optic window and then the sampling orifice of the mass spectrometer.
A mass spectrometry system, comprising:
- a mass spectrometer having a first end and a second end opposite the first end;
- a sample substrate for holding a sample at the first end of the mass spectrometer;
- a laser generator located at the second end of the mass spectrometer that emits a laser beam toward the sample substrate at the first end of the mass spectrometer to ionize the sample;
- and
- a detector for detecting the ionized sample.
A mass spectrometry system, comprising:
- a mass spectrometer having a first end and a second end opposite the first end;
- a laser generator that produces a laser radiation beam that travels along a first path;
- and
- a sample substrate for holding a sample at the first end of the mass spectrometer, wherein the sample produces a plurality of ions that travels along a second path towards the second end of the mass spectrometer that is substantially parallel the first path.
A method of matrix assisted laser dissociation ionization of a sample, comprising:
- providing a mass spectrometer having a first end and a second end, wherein the first end includes a sampling orifice and the second end includes an optic window, and wherein the sampling orifice is in-line with the optic window;
- providing a laser system located at the second end of the mass spectrometer and positioned in-line with the optic window and sampling orifice;
- producing laser radiation that passes through the optic window and the sampling orifice of the mass spectrometer and impinges upon the sample producing at least one ion from the sample.
Dependencies are inferred from the claim text.