Transgenic swine having HLA-D gene, swine cells thereof and xenografts therefrom
AssigneeAnimal Technology Institute Taiwan
InventorsChing-Fu Tu, Chun-Jean Lee, Jang-Ming Lee, Kimiyoshi Tsuji
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Abstract
The invention provides a transgenic swine having a transgene encoding a human HLA-DQ or HLA-DR protein, and the swine cells thereof. The invention also provides a graft derived from the transgenic swine, in particular a graft-organ or a graft-tissue, which is useful for grafting into a human recipient.
Claims5
A transgenic swine, whose genome includes an HLA-DQ transgene, wherein said HLA-DQ transgene comprises a combination of human HLA-DQA1 and HLA-DQB1 transgene operably linked to a constitutive promoter, and wherein expression of said transgene reduces a xenogenic cellular response between cells from said transgenic swine and a human subject.
An isolated swine cell, whose genome includes an HLA-DQ transgene, wherein said HLA-DQ transgene comprises a combination of human HLA-DQA1 and HLA-DQB1 transgene operably linked to a constitutive promoter, and wherein expression of said transgene reduces a xenogenic cellular response between said cell and a human cell.
A tissue or organ derived from a transgenic swine, whose genome includes an HLA-DQ transgene, wherein said HLA-DQ transgene comprises a combination of human HLA-DQA1 and HLA-DQB1 transgene operably linked to a constitutive promoter, and wherein expression of said transgene reduces a xenogenic cellular response between cells from said transgenic swine and a human subject.
Dependencies are inferred from the claim text.