5-thia-ω-(substituted phenyl)-prostaglandin E alcohols, process for preparing the alcohols and pharmaceutical preparations containing the same as the active ingredient

A 5-thia-ω-substituted phenyl-prostaglandin E alcohol of the formula (I)

• (wherein, —A— is absent or —A— is methylene or ethylene,
• R1 is hydrogen, C1-6 alkyl, phenyl-C1-6 alkyl, C2-6 alkanoyl, or phenyl-C2-6
• alkanoyl,
• R2 is oxo or halogen,
• R3 is hydrogen or hydroxy,
• R4a and R4b are, independently, hydrogen or C1-4 alkyl,
• R5 is phenyl substituted with the following group:
• i) 1-3 of group selected from the group consisting of
• C1-4 alkyloxy-C1-4 alkyl,
• C2-4 alkenyloxy-C1-4 alkyl,
• C2-4 alkynyloxy-C1-4 alkyl,
• C3-7 cycloalkyloxy-C1-4 alkyl,
• C3-7 cydoalkyl(C1-4 alkyloxy)-C1-4 alkyl,
• phenyloxy-C1-4 alkyl,
• phenyl-C1-4 alkyloxy-C1-4 alkyl,
• C1-4 alkylthio-C1-4 alkyl,
• C2-4 alkenylthio-C1-4 alkyl,
• C2-4 alkynylthio-C1-4 alkyl,
• C3-7 cycloalkylthio-C1-4 alkyl,
• C3-7 cycloalkyl(C1-4 alkylthio-)-C1-4 alkyl,
• phenylthio-C1-4 alkyl, and
• phenyl-C1-4 alkylthio-C1-4 alkyl,
• ii) C1-4 alkyloxy-C1-4 alkyl and C1-4 alkyl,
• C1-4 alkyloxy-C1-4 alkyl and C1-4 alkyloxy,
• C1-4 alkyloxy-C1-4 alkyl and hydroxy,
• C1-4 alkyloxy-C1-4 alkyl and halogen,
• C1-4 alkylthio-C1-4 alkyl and C1-4 alkyl,
• C1-4 alkylthio-C1-4 alkyl and C1-4 alkyloxy,
• C1-4 alkylthio-C1-4 alkyl and hydroxy, or
• C1-4 alkylthio-C1-4 alkyl and halogen,
• iii) haloalkyl or hydroxy-C1-4 alkyl, or
• iv) C1-4 alkyl and hydroxy;
• is a single bond or a double bond)
• or cyclodextrin clathrate thereof.