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US 6,639,089 B2Granted
Anticancer agents, perfumes or foods and drinks
AssigneeSoda Aromatic Co., Ltd.
InventorsNobuhiko Ito, Hiroyuki Tsuji, Yoshio Fukuda
Life of this patent
Estimating the term…
Abstract
Anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of ω-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures.
Claims23
An anticancer agent comprising, as an active ingredient, at least one compound selected from the group consisting of:
- an ω-hydroxy fatty acid represented by general formula (1) or a salt or ester thereof:
- HO—R1—COOH (1)
- wherein R1 is a straight carbon chain having 10 to 25 carbon atoms, with no or one double bond, where an alkyl or alkylene group having 1 to 4 carbon atoms or a hydroxyl group may be linked to any position as a side chain;
- a hydroxy oxo-fatty acid represented by general formula (2) or a salt or ester thereof:
- R2—COOH (2)
- wherein R2 is a saturated straight carbon chain having 9 to 25 carbon atoms, with at least one carbonyl group and at least one hydroxyl group, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain;
- a lactone represented by general formula (3):
- wherein R3 is a carbon chain having 2 to 24 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, or a carbon chain having 8 to 24 carbon atoms with at least one oxygen atom in any position which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain;
- R4 is hydrogen, a hydroxyl group, or a carbon chain having 1 to 30 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position;
- and the dashed line represents a single bond or a double bond;
- a macrocyclic ketone represented by general formula (4):
- wherein R5 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms;
- R6 is a carbon chain having 7 to 17 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain;
- R7 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms;
- and the dashed line represents a single bond or a double bond;
- and
- a macrocyclic diester represented by general formula (5)
- wherein R8 is a carbon chain having 2 to 10 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position;
- and R9 is a carbon chain having 8 to 20 carbon atoms which is saturated or unsaturated by including at least one carbon-carbon double bond in any position.
16 more elements
An anticancer agent comprising, as an active ingredient, at least one compound selected from the group consisting of:
- an ω-hydroxy fatty acid represented by general formula (1) or a salt thereof:
- HO—R1—COOH (1)
- wherein R1 is a straight carbon chain having 10 to 25 carbon atoms, with no or one double bond, where an alkyl or alkylene group having 1 to 4 carbon atoms or a hydroxyl group may be linked to any position;
- a hydroxy oxo-fatty acid represented by general formula (2) or a salt thereof:
- R2—COOH (2)
- wherein R2 is a saturated straight carbon chain having 9 to 25 carbon atoms, with at least one carbonyl group and at least one hydroxyl group, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position as a side chain;
- a macrocyclic lactone represented by general formula (3):
- wherein R3 is a carbon chain having 8 to 24 carbon atoms which is saturated or unsaturated by including one or two carbon-carbon double bonds in any positions, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position;
- R4 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms;
- and the dashed line represents a single bond or a double bond;
- and
- a macrocyclic ketone represented by general formula (4):
- wherein R5 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms;
- R6 is a carbon chain having 7 to 17 carbon atoms which is saturated or unsaturated by including one or two carbon-carbon double bonds in any position, where an alkyl or alkylene group having 1 to 4 carbon atoms may be linked to any position;
- R7 is hydrogen or an alkyl or alkylene group having 1 to 4 carbon atoms;
- and the dashed line represents a single bond or a double bond.
13 more elements
Dependencies are inferred from the claim text.