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US 6,639,083 B1Granted
Method for preparing a thiopene derivative
AssigneeSanofi-Synthelabo
InventorsMichel Biard, André Bousquet
Life of this patent
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Abstract
The invention relates to a process for preparing 2-thienyl-2-ethanol, in which: a) thiophene is metallated using an alkali metal, in the presence of an electron transfer agent, b) the compound obtained is treated with ethylene oxide, c) the thienyl derivative thus formed is hydrolyzed, to give the desired compound. 2-Thienyl-2-ethanol is a synthetic intermediate.
Claims16
A process for preparing 2-thienyl-2-ethanol, wherein:
- a) thiophene is metallated using a dispersion of a finely divided alkali metal in a medium that is not electron-donating, in the presence of an electron transfer agent,
- b) the compound obtained is treated with ethylene oxide,
- c) the thienyl compound thus formed is hydrolyzed, to give the desired compound.
Dependencies are inferred from the claim text.